Description:
Polycaprolactone (PCL) has high permeability for drug molecules and slow degradation kinetics, making it suitable for developing controlled drug delivery systems. It is a cost-effective polymer that does not create an acidic environment during degradation.
Additionally, it has many characteristics like biocompatibility, biodegradability, and non-immunogenicity, along with hydrophobic semi-crystalline properties. PCL is an FDA-approved polymer for pharmaceutical applications and has long been used in the pharmaceutical industry for the development of drug delivery systems.
By attaching drugs or biological/chemical entities to the surface of the PCL microspheres, the microspheres can be used as a carrier. PCL microspheres are used for controlled release, sustained release and targeted drug delivery. The degradation rate of PCL is slower than PLGA.
Properties and Specification:
| Average Diameter | 30-50 μm |
| storage temp | -20°C |
| PCL particles are made with poly(Ɛ-caprolactone). To re-constitute | • Warm to ambient temperature |
| • Add DI water or buffer to achieve desired concentration | |
| • Vortex and sonicate for 5 minutes to ensure particles are well suspended |
10 mg/ml particle suspension in DI water. Sonicate or vortex the particles before each use.
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